Ever since the episode "The 21-Second Excitation", Amy considers Penny to be her best friend and claims that their menses are synchronized. She often calls her "bestie".

She gets constipated by travel.

Amy's profession as a neurobiologist is likely a reference to Mayim Bialik, who plays Amy and is also an educated neuroscientist.

She wears menstrual pads all the time to avoid surprises.

Prior to The 21-Second Excitation, the closest she had ever come to a slumber party was a night she spent at a hospital with a Vietnamese girl after having her tonsils removed (the girl didn't survive the night, but "up until then, it was kinda fun").

Amy is pseudo-engaged to a Saudi prince she met at a fundraising trip to his country. In return, he funded her lab. Through him, she also has a place to stay in Riyadh during the winter.

Amy is very prone to night terrors.

Amy has volunteered for scientific experiments in which orgasm are achieved by stimulating the pleasure center of the brain, it was stimulated at least 128 times in total, in an unspecified amount of experiments.

She claims to have perfected many "tension relief techniques for ladies" over the years.

She has an electric tooth brush she uses for masturbation called "Gerard".

She claims Sheldon to be the most fun person she knows.

In the episode "The Bat Jar Conjecture" (season one, episode 13), Leonard, Howard and Raj are searching for a replacement member of their trivia bowl team, Raj mentions using the girl from TV's "Blossom", as she has a Ph.D. in Neuroscience. The girl he's referring to is Mayim Bialik, who plays Amy.

In The Herb Garden Germination, she mentions that her lab was given a grant to study addiction. She trained a monkey, Ricky, to smoke and began keeping it at home, arguing: "I'm giving him emphysema, the least I can do is let him hang out and watch cable."

She was in the Cub Scouts for two years until they discovered that she was a girl.

The closest thing to a friend Amy had in high school was a janitor with whom she regularly had lunch with until his wife called her a "puta" (Spanish for "whore") and made her stop.

She has a Ph.D. in Neurobiology. Sheldon confirmed she has a doctorate in The Roommate Transmogrification when he says, "Your doctorate is in Neurobiology, I fail to see the distinction."

Her first appearance is in "The Lunar Excitation".

She believes Neurobiology to be superior to Microbiology.

She can play the harp as shown in The Infestation Hypothesis and knows two songs, a Bossanova standard and the "Different Strokes" theme song.

She has her own secret language, Op, formed by appending -op to consonants. I.E. "Pack a bag" becomes "Pop a cop kop a bop a gop."

She wears clothes handed down to her from her grandmother, except for a pair of leopard-spotted panties she brought from Victoria's Secret.

Unlike Sheldon, Amy has no interest in model trains

Like Leonard, Amy wasn't popular in school and didn't have friends; the only person who signed her High School yearbook was her mom, who wrote, "Dear Amy, Self-respect and a hymen are better than friends and fun, love Mom."

Amy has hinted that she may be bisexual or bicurious, especially with regards to Penny. During one of their initial encounters, she asks Penny if she is a homosexual, and later attempts to engage in "harmless lesbian experimentation" with her during the girls' impromptu slumber party. In "The Pulled Groin Extrapolation", she tells Penny that she would "have a better shot with her" than Leonard.